For many Medicare beneficiaries looking for chronic gout treatment, Krystexxa (Pegloticase) can be a critical medication. If you have tried other forms of treatment for your gout with little success, Krystexxa can be a path to a more pain-free life. Krystexxa might be covered by Medicare Part D, and it will be covered by Medicare Part B. But which option saves you more money out-of-pocket? Let's dig deeper.
Krystexxa (Pegloticase) is an FDA-approved treatment for chronic gouty arthritis. It works by breaking down uric acid in the bloodstream, which can reduce inflammation and pain associated with gout. Krystexxa comes in a powder form that is dissolved in water and injected into muscles or under the skin. Other forms of treatment for gout include diet and lifestyle changes, medications such as allopurinol or colchicine, and joint injections of anesthetic or steroid medications. If these other options do not work for you, Krystexxa might be able to help.
Medicare Part B covers the cost of many drug therapies, including the cost of Krystexxa. If you have a Part D prescription drug plan, your plan might cover a portion or all of the cost for drugs like Krystexxa, depending on what is in your plan's formulary.
Medicare Part B covers the cost of Krystexxa, but you must meet certain criteria to be eligible for coverage. You must have a doctor's prescription for the drug and your doctor must specify that it is medically necessary, as well as provide documentation supporting their medical opinion. Your doctor also needs to certify that you tried other treatments.
If you're getting coverage for your Krystexxa on Part B, you might be responsible for 20% of the cost that Medicare does not cover. If you have a Medicare Supplement plan, that could cover some or all of that 20%. The average cost of could run as high as $60,000 per year, so that 20% could be as much as $12,000.
Medicare Part D might also cover a portion or all of the cost for drugs like Krystexxa. Contact your insurance plan provider to find out and ask if they cover Krystexxa in their formulary.
Krystexxa can cause side effects, including nausea, vomiting, abdominal pain and heartburn. Other possible side effects include anemia, elevated blood pressure, low white blood cell counts and allergic reactions such as itching or hives. It's important to talk to your doctor about any potential risks before starting treatment with Krystexxa.
It is important to find a doctor who understands how to use Krystexxa properly and will monitor your progress while you are using it. Ask your primary care provider if they know of any doctors in your area who specialize in gout treatment. You can also search online for physicians who specialize in gout treatment or contact the drug's manufacturer, Savient Pharmaceuticals, to find a doctor near you.
Living with gout can be difficult, but there are some things you can do to make it easier. Eating a healthy diet and exercising regularly can help reduce inflammation and pain associated with gout attacks. Drinking plenty of water helps flush through the uric acid crystals in your system that causes the pain. Avoiding or reducing processed foods, high-purine foods, and alcohol can help reduce the frequency of gout attacks. Lastly, talk to your doctor about other forms of treatment that might be more suitable for you.
In conclusion, Krystexxa (Pegloticase) is an important treatment option for those with chronic gouty arthritis who have not had success with other forms of treatment. Medicare Part B and Part D might cover some or all of the cost of your prescription. You should check in with your doctor to see if Krystexxa is right for you and your plan provider to see how you can receive coverage through Medicare. This content is for informational purposes only. If you have additional questions about your Medicare plan, call one of our experts today at 1-888-376-2028.

What's the Deal with Flex Cards?
Dec 15, 2022

Does Medicare Cover Cold Laser Therapy (CLT)?
Jun 14, 2023

Does Medicare Cover Robotic Surgery?
Nov 28, 2022

Does Medicare Pay for Varicose Vein Treatment?
Nov 18, 2022

10 Top Medicare Supplement (Medigap) Companies for 2025
Jul 14, 2025

Does Medicare Cover TENS Units?
Nov 23, 2022

Does Medicare Cover Shock Wave Therapy for Plantar Fasciitis?
Nov 30, 2022

Does Medicare Cover Light Therapy for Psoriasis?
Jan 17, 2023

Medicare Deductibles Resetting in 2025
Jan 18, 2024

Medicare Advantage MSA Plans
May 17, 2023

Medicare 101
May 20, 2020

What is a Medicare Beneficiary Ombudsman?
Apr 11, 2023

13 Best Ways for Seniors to Stay Active in Indianapolis
Mar 9, 2023

How Do Medicare Agents Get Paid?
Apr 12, 2023

Does Medicare Cover Cartiva Implants?
Nov 29, 2022

How Do I Sign up for Medicare? A Simple How-To Guide For You
Apr 8, 2022

Does Medicare pay for Opdivo?
Nov 23, 2022

Does Medicare cover Hyoscyamine?
Nov 30, 2022
13 Best Ways for Seniors to Stay Active in Philadelphia
14 Best Ways for Seniors to Stay Active in Washington, D.C.
14 Best Ways to Stay Active in Charlotte
2024 Cost of Living Adjustment
2024 Fair Square Client Retention and Satisfaction Report
2025 Medicare Price Changes
Are Medicare Advantage Plans Bad?
Can Doctors Choose Not to Accept Medicare?
Can I Have Two Primary Care Physicians?
Comparing All Medigap Plans | Chart Updated for 2025
Do You Need Books on Medicare?
Does Medicare Cover Air Purifiers?
Does Medicare Cover Boniva?
Does Medicare Cover Cardiac Ablation?
Does Medicare Cover Cervical Disc Replacement?
Does Medicare Cover Compounded Medications?
Does Medicare Cover COVID Tests?
Does Medicare Cover Driving Evaluations?
Does Medicare Cover Exercise Physiology?
Does Medicare Cover Geri Chairs?
Does Medicare Cover Hepatitis C Treatment?
Does Medicare Cover Hypnotherapy?
Does Medicare Cover Incontinence Supplies?
Does Medicare Cover Ketamine Infusion for Depression?
Does Medicare Cover Krystexxa?
Does Medicare Cover LVAD Surgery?
Does Medicare Cover Medical Marijuana?
Does Medicare Cover Mental Health?
Does Medicare Cover Mouth Guards for Sleep Apnea?
Does Medicare Cover Nexavar?
Does Medicare Cover Nuedexta?
Does Medicare Cover Ofev?
Does Medicare Cover Orthodontic Care?
Does Medicare Cover Oxybutynin?
Does Medicare Cover Piqray?
Does Medicare Cover SIBO Testing?
Does Medicare Cover Tymlos?
Does Medicare Pay for Antivenom?
Does Medicare Pay for Funeral Expenses?
Everything About Your Medicare Card + Medicare Number
Fair Square Client Newsletter: AEP Edition
Finding the Best Dental Plans for Seniors
Gap Health Insurance: The Secret Sidekick to Your High-Deductible Plan
How Does Medicare Cover Colonoscopies?
How Much Does Medicare Part B Cost in 2025?
How Much Does Open Heart Surgery Cost with Medicare?
How Much Does Rexulti Cost with Medicare?
How Much Does Trelegy Cost with Medicare?
How Often Can I Change Medicare Plans?
How to Compare Medigap Plans in 2025
How to Enroll in Social Security
Is Botox Covered by Medicare?
Is Displacement Affecting Your Medicare Coverage?
Is Emsella Covered by Medicare?
Is Gainswave Covered by Medicare?
Is the Shingles Vaccine Covered by Medicare?
Medicare Advantage Plans for Disabled People Under 65
Medicare Consulting Services
Medicare Guaranteed Issue Rights by State
Medicare Savings Programs in Kansas
Medicare Supplement Plans for Low-Income Seniors
The Easiest Call You'll Ever Make
Turning 65 and Thinking of Keeping COBRA? Here’s Why It Usually Backfires
What Does Medicare Cover for Stroke Patients?
What Happens to Unused Medicare Set-Aside Funds?
What Is a Medicare Supplement SELECT Plan?
What is Plan J?
What Is the Medicare Birthday Rule in Nevada?
What People Don't Realize About Medicare
What's the Difference Between HMO and PPO Plans?
When to Choose Medicare Advantage over Medicare Supplement
Why You Should Keep Your Medigap Plan
Get the Fair Square Bulletin
Medicare savings tips, helpful guides, and more.
Virgil Insurance Agency, LLC (DBA Fair Square Medicare) and www.fairsquaremedicare.com are privately owned and operated by Help Button Inc. Medicare supplement insurance plans are not connected with or endorsed by the U.S. government or the federal Medicare program. This is a solicitation of insurance. A licensed agent/producer may contact you. Medicare Supplement insurance is available to those age 65 and older enrolled in Medicare Parts A and B and, in some states, to those under age 65 eligible for Medicare due to disability or End-Stage Renal disease. Virgil Insurance Agency is a licensed and certified representative of Medicare Advantage HMO, HMO SNP, PPO, PPO SNP and PFFS organizations and stand-alone PDP prescription drug plans. Each of the organizations we represent has a Medicare contract. Enrollment in any plan depends on contract renewal. The plans we represent do not discriminate on the basis of race, color, national origin, age, disability, or sex. Plan availability varies by region and state. For a complete list of available plans please contact 1-800-MEDICARE (TTY users should call 1-877-486-2048), 24 hours a day/7 days a week or consult www.medicare.gov. © 2025 Help Button Inc
We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1-800-MEDICARE to get information on all of your options.
MULTIPLAN_FairSquareMedicare_01062022_M
Fair Square Medicare
