Fair Square Medicare Wordmark

Does Medicare Cover Krystexxa?

The feet of a man suffering from foot pain stock photo
By Daniel Petkevich
Nov 18, 2022

Yes, but how it's covered could save you money

For many Medicare beneficiaries looking for chronic gout treatment, Krystexxa (Pegloticase) can be a critical medication. If you have tried other forms of treatment for your gout with little success, Krystexxa can be a path to a more pain-free life. Krystexxa might be covered by Medicare Part D, and it will be covered by Medicare Part B. But which option saves you more money out-of-pocket? Let's dig deeper.

Stay Up to Date on Medicare!

Join the Fair Square Medicare Newsletter to stay informed on cost savings, changes to Medicare, and other valuable healthcare information.

What is Krystexxa?

Krystexxa (Pegloticase) is an FDA-approved treatment for chronic gouty arthritis. It works by breaking down uric acid in the bloodstream, which can reduce inflammation and pain associated with gout. Krystexxa comes in a powder form that is dissolved in water and injected into muscles or under the skin. Other forms of treatment for gout include diet and lifestyle changes, medications such as allopurinol or colchicine, and joint injections of anesthetic or steroid medications. If these other options do not work for you, Krystexxa might be able to help.

Does Medicare Cover Krystexxa?

Medicare Part B covers the cost of many drug therapies, including the cost of Krystexxa. If you have a Part D prescription drug plan, your plan might cover a portion or all of the cost for drugs like Krystexxa, depending on what is in your plan's formulary.

How to get Medicare to cover Krystexxa

Medicare Part B covers the cost of Krystexxa, but you must meet certain criteria to be eligible for coverage. You must have a doctor's prescription for the drug and your doctor must specify that it is medically necessary, as well as provide documentation supporting their medical opinion. Your doctor also needs to certify that you tried other treatments.
If you're getting coverage for your Krystexxa on Part B, you might be responsible for 20% of the cost that Medicare does not cover. If you have a Medicare Supplement plan, that could cover some or all of that 20%. The average cost of could run as high as $60,000 per year, so that 20% could be as much as $12,000.
Medicare Part D might also cover a portion or all of the cost for drugs like Krystexxa. Contact your insurance plan provider to find out and ask if they cover Krystexxa in their formulary.

What are the side effects of Krystexxa?

Krystexxa can cause side effects, including nausea, vomiting, abdominal pain and heartburn. Other possible side effects include anemia, elevated blood pressure, low white blood cell counts and allergic reactions such as itching or hives. It's important to talk to your doctor about any potential risks before starting treatment with Krystexxa.

How to find a doctor who can prescribe Krystexxa

It is important to find a doctor who understands how to use Krystexxa properly and will monitor your progress while you are using it. Ask your primary care provider if they know of any doctors in your area who specialize in gout treatment. You can also search online for physicians who specialize in gout treatment or contact the drug's manufacturer, Savient Pharmaceuticals, to find a doctor near you.

Tips for living with gout

Living with gout can be difficult, but there are some things you can do to make it easier. Eating a healthy diet and exercising regularly can help reduce inflammation and pain associated with gout attacks. Drinking plenty of water helps flush through the uric acid crystals in your system that causes the pain. Avoiding or reducing processed foods, high-purine foods, and alcohol can help reduce the frequency of gout attacks. Lastly, talk to your doctor about other forms of treatment that might be more suitable for you.

Takeaway

In conclusion, Krystexxa (Pegloticase) is an important treatment option for those with chronic gouty arthritis who have not had success with other forms of treatment. Medicare Part B and Part D might cover some or all of the cost of your prescription. You should check in with your doctor to see if Krystexxa is right for you and your plan provider to see how you can receive coverage through Medicare. This content is for informational purposes only. If you have additional questions about your Medicare plan, call one of our experts today at 1-888-376-2028.

Stay Up to Date on Medicare!

Join the Fair Square Medicare Newsletter to stay informed on cost savings, changes to Medicare, and other valuable healthcare information.

Recommended Articles

Dames Point Bridge in Jacksonville, Florida stock image
13 Best Ways for Seniors to Stay Active in Jacksonville
Mar 3, 2023
breast cancer awareness ribbon stock image
Does Medicare Cover Piqray?
Dec 2, 2022
Cover image
Can I Use Medicare Part D at Any Pharmacy?
Aug 28, 2023
Caucasian nurse holding spine model against the patients backs. Clinic interior. stock photo
Does Medicare Cover SI Joint Fusion?
Nov 28, 2022
Fecal microbiota transplant from healthy in unhealthy intestine, FMT. Improvement intestinal microflora and normalization stool by introducing beneficial bacteria in bowel colon tract. Vector stock illustration
Does Medicare Cover an FMT?
Dec 2, 2022
Screenshot 2025-03-19 at 5.02.46 PM
2024 Fair Square NPS Report
Mar 19, 2025
Kansas farm stock photo
Medicare Savings Programs in Kansas
Mar 22, 2023
Pile of junk in a house, hoarder room pile of household equipment needs clearing out stock photo
Does Medicare Cover Hoarding Cleanup?
Jan 10, 2023
male driver taking notes from behind the wheel stock image
Does Medicare Cover Driving Evaluations?
Dec 1, 2022
Cover image
2024 Cost of Living Adjustment
Nov 13, 2023
Leg bones and knees, 3d rendering. stock photo
Does Medicare Cover Boniva?
Nov 29, 2022
Abortion stock image
Does Medicare Cover Abortion Services?
Dec 13, 2022
Cover image
How Much Does a Medicare Coach Cost?
Mar 20, 2023
Medicare at 62 stock image
Does Retiring at Age 62 Make Me Eligible for Medicare?
Jun 16, 2022
various cartoon scenarios showing long term care stock photo
Which Medigap Policies Provide Coverage for Long-Term Care?
Sep 16, 2022
Cover image
2025 Medicare Price Changes
Oct 30, 2023
Cover image
Does Medicare Cover Cold Laser Therapy (CLT)?
Jun 14, 2023
Human hands holding healthy lung shape made from paper on light blue background. stock photo
How Much Does Trelegy Cost with Medicare?
Jan 24, 2023

More of our articles

13 Best Ways for Seniors to Stay Active in Indianapolis

13 Best Ways for Seniors to Stay Active in Philadelphia

13 Best Ways for Seniors to Stay Active in Phoenix

14 Best Ways for Seniors to Stay Active in Nashville

15 Best Ways for Seniors to Stay Active in Denver

Are Medicare Advantage Plans Bad?

Can Doctors Choose Not to Accept Medicare?

Can I Change Medicare Advantage Plans Any Time? | Medicare Plans

Can I Laminate My Medicare Card?

Costco Pharmacy Partners with Fair Square

Do I Need Medicare If My Spouse Has Insurance?

Do Medicare Supplement Plans Cover Dental and Vision?

Do You Need Books on Medicare?

Does Medicare Cover a Spinal Cord Stimulator?

Does Medicare Cover Bladder Sling Surgery?

Does Medicare Cover Cardiac Ablation?

Does Medicare Cover Cervical Disc Replacement?

Does Medicare Cover Chiropractic Visits?

Does Medicare Cover Cosmetic Surgery?

Does Medicare Cover Diabetic Eye Exams?

Does Medicare Cover Fosamax?

Does Medicare Cover Home Heart Monitors?

Does Medicare Cover Incontinence Supplies?

Does Medicare Cover Iovera Treatment?

Does Medicare Cover Krystexxa?

Does Medicare Cover Linx Surgery?

Does Medicare Cover Medical Marijuana?

Does Medicare Cover Mental Health?

Does Medicare Cover Nuedexta?

Does Medicare Cover Ofev?

Does Medicare Cover Oxybutynin?

Does Medicare Cover SIBO Testing?

Does Medicare Cover Tymlos?

Does Medicare Cover Urodynamic Testing?

Does Medicare Cover Vitamins?

Does Medicare Cover Xiafaxan?

Does Medicare Pay for Bunion Surgery?

Does Medicare Pay for Funeral Expenses?

Does Medicare Require a Referral for Audiology Exams?

Estimating Prescription Drug Costs

Fair Square Client Newsletter: AEP Edition

Health Savings Accounts (HSAs) and Medicare

How Are Medicare Star Ratings Determined?

How Do Medicare Agents Get Paid?

How Does Medicare Cover Colonoscopies?

How Does Medicare Pay for Emergency Room Visits?

How is Medicare Changing in 2025?

How Much Does a Pacemaker Cost with Medicare?

How Much Does Medicare Part B Cost in 2025?

How Much Does Open Heart Surgery Cost with Medicare?

How Much Does Xeljanz Cost with Medicare?

How Often Can I Change Medicare Plans?

How to Become a Medicare Agent

How to Deduct Medicare Expenses from Your Taxes

Is Botox Covered by Medicare?

Is Fair Square Medicare Legitimate?

Is HIFU Covered by Medicare?

Medicare Advantage Plans for Disabled People Under 65

Medicare Deductibles Resetting in 2025

Medicare Guaranteed Issue Rights by State

Medicare Supplement Plans for Low-Income Seniors

Top 10 Physical Therapy Clinics in San Diego

What Does Medicare Cover for Stroke Patients?

What is a Medicare Beneficiary Ombudsman?

What Is Medical Underwriting for Medigap?

What People Don't Realize About Medicare

What You Need to Know About Creditable Coverage

What's the Deal with Flex Cards?

When Can You Change Medicare Supplement Plans?

When to Choose Medicare Advantage over Medicare Supplement

Will Medicare Cover Dental Implants?

Will Medicare Cover it?

Your Medicare One-Stop-Shop

Your guide to Medicare Parts A & B, Medicare Advantage, and Medigap. 100% free.
Get the Fair Square Bulletin

Medicare savings tips, helpful guides, and more.

About

Medicare 101

Current Clients

Medicare Supplement Plans

Medicare Advantage Plans

Fair Square 2025

Terms of Use
Notice of Privacy Practices

Virgil Insurance Agency, LLC (DBA Fair Square Medicare) and www.fairsquaremedicare.com are privately owned and operated by Help Button Inc. Medicare supplement insurance plans are not connected with or endorsed by the U.S. government or the federal Medicare program. This is a solicitation of insurance. A licensed agent/producer may contact you. Medicare Supplement insurance is available to those age 65 and older enrolled in Medicare Parts A and B and, in some states, to those under age 65 eligible for Medicare due to disability or End-Stage Renal disease. Virgil Insurance Agency is a licensed and certified representative of Medicare Advantage HMO, HMO SNP, PPO, PPO SNP and PFFS organizations and stand-alone PDP prescription drug plans. Each of the organizations we represent has a Medicare contract. Enrollment in any plan depends on contract renewal. The plans we represent do not discriminate on the basis of race, color, national origin, age, disability, or sex. Plan availability varies by region and state. For a complete list of available plans please contact 1-800-MEDICARE (TTY users should call 1-877-486-2048), 24 hours a day/7 days a week or consult www.medicare.gov. © 2025 Help Button Inc

We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1-800-MEDICARE to get information on all of your options.

MULTIPLAN_FairSquareMedicare_01062022_M