Fair Square Medicare Wordmark

Does Medicare Cover Ketamine Infusion for Depression?

Dripping medication stock photo
By Ford Carlisle
Nov 23, 2022

Ways to Cover Your Ketamine Therapy Costs

If you or your loved ones

struggle with depression

and haven't found relief from traditional medications, you might consider ketamine infusion therapy. This alternative mental health therapy has proven effective for individuals with treatment-resistant depression.

Stay Up to Date on Medicare!

Join the Fair Square Medicare Newsletter to stay informed on cost savings, changes to Medicare, and other valuable healthcare information.
But what exactly is ketamine infusion, and will your insurance plan help cover the costs?
Keep reading to find out. In this article, we'll answer all your questions about ketamine infusion therapy and discuss ways to get coverage.

What Is Ketamine Infusion Therapy?

Ketamine infusion is an FDA-approved therapy for treatment-resistant depression.
It involves a 40-minute procedure — in a hospital or clinical setting — in which a doctor administers ketamine intravenously.
Ketamine infusion therapy requires multiple sessions:
  • It begins with an induction period — the patient typically receives six infusions over 2-3 weeks
  • Then follows the maintenance period — the dosage is slowly reduced to one infusion every 2-6 weeks

How Much Does Ketamine Infusion Therapy Cost?

A single ketamine infusion costs between $450 and $500.
The total cost of the Ketamine infusion therapy — which includes six ketamine infusions, a pretreatment consultation, and post-treatment follow-ups — is around $4,500.
Exact treatment costs may vary depending on your healthcare provider.

Does Medicare Cover Ketamine Infusions?



doesn't cover ketamine treatments for mental health conditions — like depression, anxiety, or mood disorders.
However, Medicare does cover a derivative of ketamine known as esketamine (Spravato). Spravato is an FDA-approved intranasal spray used on patients with treatment-resistant depression.
Note: To get Medicare coverage for Spravato,

you must be enrolled

in Medicare Part D or any Medicare Advantage Plan that covers prescription drugs. (Medicare Parts A and B don't cover Spravato).

Do Private Insurance Companies Cover Ketamine Infusions?

Typically, no.
Most private insurance companies only cover ketamine as an anesthetic. They probably won't cover ketamine treatments for depression.
However, insurance might cover certain parts of your treatment — like doctor visits or medical exams.
The extent of your insurance coverage depends on your plan and provider.

How Can I Cover the Costs of Ketamine Infusions?

Here are some ways to make ketamine infusions more affordable:
  • Talk to your insurance provider
  • Look for out-of-network reimbursements
  • Provide a Superbill
  • Use HSA/FSA accounts
  • Look into Advance Care
  • Seek Veteran Support
  • Ask about installment payments
Let's look at each option in more detail.

1. Talk to Your Insurance Provider

Check whether your insurance provider covers ketamine therapy. Some offer coverage under specific circumstances:
  • For example, if your provider classifies the treatment as “an infusion of a generic drug,” they may be able to cover some out-of-pocket expenses

2. Look for Out-of-Network Reimbursements

See if your insurance provider reimburses out-of-network claims. Pay your clinical provider for the service and ask your insurance for a reimbursement.
Most insurance companies accept out-of-network claims for healthcare services — unless their policy states otherwise. But each insurance company has different rules regarding out-of-network coverage. Talk to your provider for more info.

3. Provide a Superbill

A Superbill is an itemized list of all services provided to a client. It includes detailed visit summaries, doctors' names, CPT codes, etc.
Request a Superbill from your doctor. You might need it to claim your out-of-network coverage or get financial assistance with doctor visits, medical exams, etc.

4. Use HSA/FSA Accounts

HSA (Healthcare Spending Account) and FSA (Flexible Spending Account) are pre-tax accounts that help you save money for qualified healthcare expenses. 
Paying for your ketamine therapy using these "pre-tax" dollars is like receiving a discount on your treatment.
Note: Stop HSA contributions at least six months before enrolling in Medicare to avoid potential tax penalties.

5. Look Into Advance Care

Advance Care

provides patients with affordable medical financing options. The Advance Care Card offers interest-free financing, affordable monthly payments, and flexible terms.
Using Advance Care can help reduce up-front expenses.

6. Seek Veteran Support

The Ketamine Fund

offers free ketamine therapy to veterans suffering from PTSD, anxiety, depression, and other treatment-resistant disorders.

7. Ask About Installment Payments

Ask your healthcare provider if they provide installment payment options. Enrolling in a payment plan can help you cover up-front treatment costs.

Will Ketamine Infusion Coverage Change in the Future?

It's possible! Insurance companies might decide to cover ketamine infusion therapy as more research shows its safety and effectiveness in treating depression. 
Several organizations are already trying to spark this change:
For example, a non-profit organization called the

Ketamine Task Force

works to make ketamine infusion therapy more accessible. Their goal is to get insurance providers to approve coverage for ketamine infusions and provide fair reimbursement rates to ketamine providers.


Ketamine infusion therapy is an effective depression treatment — with results lasting days or weeks. Talk with your doctor before starting or stopping treatment for depression. This content is for informational purposes only.
Currently, Medicare doesn't provide coverage of ketamine treatments for depression. But you can seek out-of-network reimbursements, HSA/FSA accounts, and other payment options to reduce your expenses.
If you need help, our team at

Fair Square Medicare

has your back. Our advisors can answer any questions you have about Medicare coverage.
Give us a call at 1-888-376-2028.

Stay Up to Date on Medicare!

Join the Fair Square Medicare Newsletter to stay informed on cost savings, changes to Medicare, and other valuable healthcare information.

Recommended Articles

Asian senior male patient having him eyes examined by laser machine
Finding the Best Vision Plans for Seniors
Jan 6, 2023
Model of the lungs with the diseased part stock photo
Does Medicare Cover Ofev?
Dec 2, 2022
Cover image
Should You Work With A Remote Medicare Agent?
Sep 20, 2023
Cover image
Does Medicare Cover Cold Laser Therapy (CLT)?
Jun 14, 2023
The feet of a man suffering from foot pain stock photo
Does Medicare Cover Krystexxa?
Nov 18, 2022
Human hands holding healthy lung shape made from paper on light blue background. stock photo
How Much Does Trelegy Cost with Medicare?
Jan 24, 2023
Cover image
How Often Can I Change Medicare Plans?
May 5, 2023
Sleep apena stock image
Does Medicare Cover Inspire for Sleep Apnea?
Dec 27, 2022
hand holding up Invisalign stock photo
Does Medicare Cover Orthodontic Care?
Nov 18, 2022
Electrocardiograph with pacemaker stock photo
How Much Does a Pacemaker Cost with Medicare?
Nov 21, 2022
Cover image
How to Become a Medicare Agent
Aug 30, 2023
Leg bones and knees, 3d rendering. stock photo
Does Medicare Cover Fosamax?
Nov 30, 2022
Last will and testament stock photo
Does Medicare Pay for Funeral Expenses?
Dec 6, 2022
Charlotte skyline stock image
14 Best Ways to Stay Active in Charlotte
Mar 9, 2023
cartoon hospital and male doctor stock image
Can I Have Two Primary Care Physicians?
Oct 3, 2022
Happy senior man and dentist assistant talking during appointment at dental clinic. stock photo
Finding the Best Dental Plans for Seniors
Jan 4, 2023
Cover image
2024 Medicare Price Changes
Oct 30, 2023
elderly woman with glasses having difficulty reading her phone stock image
Is Vitrectomy Surgery Covered by Medicare?
Dec 2, 2022

More of our articles

13 Best Ways for Seniors to Stay Active in Philadelphia

13 Best Ways for Seniors to Stay Active in Phoenix

14 Best Ways for Seniors to Stay Active in Washington, D.C.

2024 "Donut Hole" Updates

Building the Future of Senior Healthcare

Can Doctors Choose Not to Accept Medicare?

Can I Change Medicare Advantage Plans Any Time? | Medicare Plans

Can I Change My Primary Care Provider with an Advantage Plan?

Can I Choose Marketplace Coverage Instead of Medicare?

Do All Hospitals Accept Medicare Advantage Plans?

Do I Need Medicare If My Spouse Has Insurance?

Do You Need Books on Medicare?

Does Medicare Cover Air Purifiers?

Does Medicare Cover Bariatric Surgery?

Does Medicare Cover Cataract Surgery?

Does Medicare Cover Cervical Disc Replacement?

Does Medicare Cover COVID Tests?

Does Medicare cover Deviated Septum Surgery?

Does Medicare Cover ESRD Treatments?

Does Medicare Cover Exercise Physiology?

Does Medicare Cover Geri Chairs?

Does Medicare Cover Hearing Aids?

Does Medicare Cover Hypnotherapy?

Does Medicare Cover Incontinence Supplies?

Does Medicare Cover Iovera Treatment?

Does Medicare Cover Qutenza?

Does Medicare Cover Robotic Surgery?

Does Medicare Cover Scleral Lenses?

Does Medicare Cover Shock Wave Therapy for Plantar Fasciitis?

Does Medicare Cover SIBO Testing?

Does Medicare Cover Stair Lifts?

Does Medicare Cover the Urolift Procedure?

Does Medicare Cover Wart Removal?

Does Medicare Pay for Allergy Shots?

Does Medicare Pay for Varicose Vein Treatment?

Does Your Medicare Plan Cover B12 Shots?

Does Your Plan Include A Free Gym Membership?

Everything About Your Medicare Card + Medicare Number

Fair Square Bulletin: We're Revolutionizing Medicare

Health Savings Accounts (HSAs) and Medicare

How Do Medicare Agents Get Paid?

How Does Medicare Pay for Emergency Room Visits?

How Does the End of the COVID-19 Public Health Emergency Affect Your Medicare?

How is Medicare Changing in 2023?

How Medicare Costs Can Pile Up

How Much Does Medicare Part A Cost in 2023?

How Much Does Open Heart Surgery Cost with Medicare?

Is Balloon Sinuplasty Covered by Medicare?

Is Botox Covered by Medicare?

Is Displacement Affecting Your Medicare Coverage?

Is Fair Square Medicare Legitimate?

Medicare & Ozempic

Medicare Advantage MSA Plans

Medicare Advantage Plans for Disabled People Under 65

Medicare Deductibles Resetting in 2024

Medicare Explained

Medicare Guaranteed Issue Rights by State

Medicare Savings Programs in Kansas

Plan G vs. Plan N

Saving Money with Alternative Pharmacies & Discount Programs

Seeing the Value in Fair Square

The Fair Square Bulletin: February 2024

The Fair Square Bulletin: November 2023

Top 10 Physical Therapy Clinics in San Diego

What Happens to Unused Medicare Set-Aside Funds?

What is a Medicare Beneficiary Ombudsman?

What is the 8-Minute Rule on Medicare?

What is the Medicare ICEP?

What's the Deal with Flex Cards?

Why You Should Keep Your Medigap Plan

Will Medicare Cover Dental Implants?

Will Medicare Cover it?

Your Medicare One-Stop-Shop

Your guide to Medicare Parts A & B, Medicare Advantage, and Medigap. 100% free.
Get the Fair Square Bulletin

Medicare savings tips, helpful guides, and more.


Medicare 101

Current Clients

Medicare Supplement Plans

Medicare Advantage Plans

Fair Square 2024

Terms of Use
Notice of Privacy Practices

Virgil Insurance Agency, LLC (DBA Fair Square Medicare) and www.fairsquaremedicare.com are privately owned and operated by Help Button Inc. Medicare supplement insurance plans are not connected with or endorsed by the U.S. government or the federal Medicare program. This is a solicitation of insurance. A licensed agent/producer may contact you. Medicare Supplement insurance is available to those age 65 and older enrolled in Medicare Parts A and B and, in some states, to those under age 65 eligible for Medicare due to disability or End-Stage Renal disease. Virgil Insurance Agency is a licensed and certified representative of Medicare Advantage HMO, HMO SNP, PPO, PPO SNP and PFFS organizations and stand-alone PDP prescription drug plans. Each of the organizations we represent has a Medicare contract. Enrollment in any plan depends on contract renewal. The plans we represent do not discriminate on the basis of race, color, national origin, age, disability, or sex. Plan availability varies by region and state. For a complete list of available plans please contact 1-800-MEDICARE (TTY users should call 1-877-486-2048), 24 hours a day/7 days a week or consult www.medicare.gov. © 2024 Help Button Inc

We do not offer every plan available in your area. Any information we provide is limited to those plans we do offer in your area. Please contact Medicare.gov or 1-800-MEDICARE to get information on all of your options.